Emergency services were called to the intersection of Darkwood Road and Waterfall Way at Thora following reports of a two car collision on Saturday, shortly before 10.30am.
A 31-year-old local man was killed at the scene while the driver of the second vehicle was conveyed to hospital for mandatory blood and urine tests.
Police from Coffs Clarence Local Area Command attended and established a crime scene.
Police will prepare a report for the information of the Coroner outlining the full circumstances surrounding the man’s death.
Local traffic diversions are in place and motorists are advised to avoid the area.
Anyone who witnessed the crash is asked to contact Crime Stoppers on 1800 333 000 or use the Crime Stoppers online reporting page.